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HLA Typing in Acute Optic Neuritis, Relation to MS & Magnetic Resonance Imaging Findings Arch Neurol 54:76-80, Frederiksen,J.L.,et al, 1997 See this aricle in Pubmed Article Abstract The frequencies of alleles were similar in patients with ON and ON+CDMS, confirming that they are not 2 immunogenetically distinct disease entities.The heterogeneity within the group of patients with ON suggests that the HLA-DR15 molecule is involved in susceptibility to initial demyelinating lesion formation.

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